Of these, three constituted mature adipocytes that were similar in size, but distinct in their spatial arrangements and transcriptional profiles. This identified 18 cell classes with unique propensities to form spatially organized homo- and heterotypic clusters. Herein, we combined spatially resolved transcriptional profiling with single-cell RNA sequencing and image analyses to map human WAT composition and structure.
The contribution of cellular heterogeneity and architecture to white adipose tissue (WAT) function is poorly understood.
