OpenEmu is another free and open-source multi-system emulator that provides the front-end interface to emulate numerous consoles, including Genesis, Game Boy, Nintendo GS, and more. OpenEmu: Best Nintendo DS Emulator for Mac. It comes with several graphics customization options and also includes a cheat code manager It supports both 32-bit and 64-bit operating systems which makes it a convenient choice for everyone. This is an open-source and one of the best Nintendo DS emulators you will find for Mac, Windows, and Linux. The GameBoy has come a long way since we first saw that big white and grey block at the end of the last century DeSmuME is a Nintendo DS emulator that allows you to play games on your Mac using DS ROM files, which you can download from the Internet.Home DS Emulator Mac NDS Emulators for Mac OS X Emuparadis